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Abstract

Triglyceride (TG) enrichment of high density lipoprotein (HDL), which occurs in hypertriglyceridemic states, significantly enhances the rate at which HDL apolipoprotein (apo)A-I is cleared from the circulation of healthy humans. In the New Zealand White (NZW) rabbit, a species naturally deficient in hepatic lipase (HL), TG enrichment of HDL requires prior lipolytic modification to enhance apoA-I clearance. However, the effect of TG enrichment of HDL on the subsequent clearance of HDL cholesteryl ester (CE) has not previously been examined in vivo. Therefore, we investigated, in the NZW rabbit, the effect of ex vivo TG enrichment of rabbit HDL (by incubation with human very low density lipoprotein) on the clearance of HDL CE and apoA-I radiolabeled with 3 H-cholesteryl oleyl ether and with 131 I, respectively. In nine experiments, TG enrichment of rabbit HDL resulted in an 87% average increase in HDL TG and a corresponding 31% reduction in HDL CE content. The calculated apoA-I and CE fractional catabolic rates associated with TG-rich versus fasting HDL tracers were not significantly different (apoA-I: 0.119 ± 0.017 vs. 0.107 ± 0.024 pools per h, P = 0.68; CE: 0.147 ± 0.014 vs. 0.114 ± 0.019 pools per h, P = 0.20). In an animal model deficient in HL, TG enrichment of HDL did not alter the rates of HDL apoA-I or selective CE clearance. Further studies are needed to determine whether, in the presence of HL, TG enrichment of HDL alters selective HDL CE clearance.

—Rashid, S., K. D. Uffelman, P. H. R. Barrett, P. Vicini, K. Adeli, and G. F. Lewis. Triglyceride enrichment of HDL does not alter HDL-selective cholesteryl ester clearance in rabbits. J. Lipid Res. 2001. 42: 265–271.

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There is a strong inverse correlation between plasma levels of high density lipoprotein cholesterol (HDL-C) and the development of atherosclerotic cardiovascular disease ( 1 , Clearance For Nice Aquazzura 2017 Cosmic Star Velvet Flats Sale Collections Cool JvCuFK
). Hypertriglyceridemia is commonly associated with low plasma levels of HDL-C ( 3 TUK Original Footwear Jute Wrapped Sole Creeper Cheap Prices Reliable OaeII
). Although the molecular mechanism accounting for this association is not entirely clear, we and other researchers have postulated that changes in HDL lipid composition secondary to hypertriglyceridemia are an important determinant of plasma HDL-C levels ( Tods RoundToe Loafer Pumps Buy Cheap 2018 New W3g90
). Indeed, we have previously demonstrated in humans that triglyceride (TG) enrichment of HDL markedly enhances the clearance of HDL-associated apolipoprotein (apo)A-I from the circulation ( 7 ).

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In this article, we look at the causes of burning sensations, when to see a doctor, and what treatments are available.

The location of the sensation can give a good indication of its cause. For example, a burning feeling in the muscles may be the result of an injury, while a burning sensation on the skin is likely the result of having come into contact with an allergen or an irritant, such as poison ivy.

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While urinating

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